Clashes broke out early Friday between Israeli police and Palestinians at the Al-Aqsa Mosque, a major holy site in Jerusalem, and medics said at least 59 Palestinians were wounded, France 24 reported.
The report quoting Islamic endowment that administers the site said Israeli police entered in force before dawn, as thousands of worshippers were gathered at the mosque for early morning prayers during the holy month of Ramadan.
Israel said its forces entered to remove rocks and stones that had been gathered in anticipation of violence.
Videos circulating online showed Palestinians hurling rocks and police firing tear gas and stun grenades. Others showed worshippers barricading themselves inside the mosque itself amid what appeared to be clouds of tear gas, the report said.
The report quoting the Palestinian Red Crescent emergency service said it evacuated 59 wounded people to hospitals. The endowment said one of the guards at the site was shot in the eye with a rubber bullet.
Meanwhile, the Israeli Foreign Ministry said dozens of masked men carrying Palestinian and Hamas flags marched to the compound early Friday and gathered stones.